The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-). The incidence ranges from 1:15,000 to 1:50,000 live-born infants. The main clinical features are a high-pitched monochromatic cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, abnormal dermatoglyphics, and severe psychomotor and 5p-Deletion. The chromosomal basis of Cri du chat syndrome consists of a deletion of the most terminal portion of the short arm of chromosome 5. 5p deletions, whether terminal or interstitial, occur at different breakpoints; the chromosomal basis generally consists of a deletion on the short arm of chromosome 5. These two short arms are referred to as p arms from the French term "petit" that means small. In cri du chat syndrome, a part of one of the short arms of chromosome 5 is missing and so cri du chat syndrome is also known as 5p deletion syndrome, or 5p minus. Okay, so 80-85% of the cases of cri du chat syndrome are the result of de novo Cri-du-Chat syndrome is a rare genetic disorder caused by missing pieces in a particular chromosome. It is not the result of parents' actions or failure to do. A newborn baby with Cri-du-Chat syndrome includes a sharp cry, a small head, and a flattened bridge of the nose. The goal of treatment is to help the child reach their full potential. Other symptoms include low birth weight, slow growth, downward slanting eyes, intellectual disability, webbed fingers or toes, abnormal ears, skin tags, small head, wide-set eyes and more. What might cause cri-du-chat syndrome? Cri-du-chat syndrome is caused by a missing portion of the short arm ("p" arm") of chromosome 5. What can you do about it? Cri du chat syndrome is often diagnosed at birth. The symptoms in a newborn baby can include: a high-pitched, cat-like cry or weak cry. low birth weight. a small head. a rounded face. a broad, flattened bridge of the nose. eyes spaced wide apart. folds of skin over the eyelids. .

symptoms of cri du chat